THERAPEUTIC PROGRESS–REVIEW XXXVII: METHOTREXATE–AN IMMUNOMODULATOR WITH EXPANDING INDICATIONS

Expanding indications for neuromodulation.

Neuromodulation in one form or another has been studied for decades for various disease states. Although its mechanism of action remains un-explained, numerous clinical success stories suggest it is a therapy with efficacy and durability. Controlled studies have led to the approval of sacral neuromodulation for urinary urgency and frequency, urinary retention, and urinary urge incontinence. The...

Expanding DBS indications: Reminder of the consequences of establishing a therapeutic practice

Peroral Endoscopic Myotomy Is Expanding Its Indications

CC This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons. org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. *Correspondence: Hee Man Kim, MD, PhD Department of Internal Medicine, Yonsei University...

Implantable cardioverter-defibrillators: expanding indications and technologies.

CONTEXT Sudden cardiac death (SCD) is a major challenge facing contemporary cardiology. For an increasing number of patients, the current standard of care for the treatment and prevention of SCD is the implantable cardioverter-defibrillator (ICD). Since its introduction, there have been numerous advances in ICD technology, and indications for its use have expanded greatly in the past year. OB...

Expanding indications for the Boston keratoprosthesis.

PURPOSE OF REVIEW To review emerging indications for the Boston keratoprosthesis (KPro) and to discuss current research underway to improve clinical outcomes. RECENT FINDINGS In addition to multiple failed corneal grafts, other ocular conditions for which the Boston KPro has been used include herpetic keratitis, aniridia, autoimmune ocular disorders, and pediatric corneal opacities. In the re...